Published 2013 (AACC Publication), 75pp
Edited by Pradip Datta, Adetoun A. Ejilemele, and John R. Petersen
The Quick Guide to Immunoassay Interference is a valuable resource for medical laboratory scientists and directors, physicians, and other clinical support personnel to identify how laboratory immunoassay results may be affected by different types of interference. The Guide’s pocket size provides immediate access about what to watch for and how to correct such aberrant results, which are now ever dependent on clinical laboratory results, and maintain the integrity of patient care.
Starting from the basics of both immunoassays and assay interference, the Guide presents various sources of assay interference: cross-reactivity, prozone effects, heterophilic antibodies, endogenous serum components, system components, and analyte heterogeneity. The Guide also includes the various sources of preanalytical interference and is intended to be used as a reference for the diagnostics and pharmaceutical industries with regard to choosing an assay design to minimize interferences and to product support specialists so they can respond to reports of erroneous results from their customers.
The Guide can be used to assist physicians, pharmacists, pathologists, physician assistants, and medical fellows, residents, and students in understanding not only how to detect erroneous immunoassay results before making clinical decisions based on them but how such interference can be resolved and correct results may be obtained. The information contained in this Quick Guide also clarifies laboratory assay utilization to help predict, diagnose, and monitor therapy for clinical conditions and disease.